Sample size determination for classifiers based on single-nucleotide polymorphisms

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Sample size determination for classifiers based on single-nucleotide polymorphisms.

Single-nucleotide polymorphisms (SNPs), believed to determine human differences, are widely used to predict risk of diseases. Typically, clinical samples are limited and/or the sampling cost is high. Thus, it is essential to determine an adequate sample size needed to build a classifier based on SNPs. Such a classifier would facilitate correct classifications, while keeping the sample size to a...

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ژورنال

عنوان ژورنال: Biostatistics

سال: 2012

ISSN: 1465-4644,1468-4357

DOI: 10.1093/biostatistics/kxr053